Role of NCOA4 in mobilizing iron stores
Nuclear receptor coactivator 4 (NCOA4) promotes the autophagic ferritin degradation in conditions of iron deficiency. Dr. Antonella Nai (Università Vita-Salute San Raffaele, Milan, Italy) addressed the role of NCOA4 in response to chronic and acute iron demand in a mouse model.
“Our results demonstrate that mice lacking the Ncoa4-gene (Ncoa4-ko), although not anemic in basal conditions, are more susceptible to iron-deficiency anemia. Their hematological phenotype is due to a defect in bone marrow-derived cells. These cells are able to reconstitute almost normal Hb levels in transplanted animals and this, accompanied by a normal erythropoiesis, indicates that in vivo Ncoa4-deficiency has a limited, if any, effect on the erythroid lineage differentiation. However, the reduced iron recycling capacity of Ncoa4-ko macrophages supports the role of NCOA4 in mobilizing iron stores.”