Role of PIEZO1 in erythroid differentiation
Activation of the mechanotransductor PIEZO1 plays a central role in erythrocyte dehydration in hereditary xerocytosis (HX), but its importance in erythropoiesis and the consequences of Piezo1 gain-of-function mutations in HX had not yet been evaluated.
Dr. Alexis Caulier (Université Picardie Jules Verne, Amiens, France) presented data of the role of PIEZO1 activation in erythroid differentiation of normal and HX-derived hematopoietic progenitors.
“PIEZO1 activation repressed erythroid terminal maturation through calcium entry and secondary phosphorylation of the ERK pathway. A similar phenotype was observed in the majority of PIEZO1-mutated HX patients but not all, underlying the high heterogeneity in the phenotype and pathophysiology of this disease.”