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Circular RNA-profiling in cytogenetically normal AML (CN-AML)
Profiling of a novel class of non-coding RNA has prognostic and biologic significance in younger adults with newly diagnosed CN-AML, as was presented by Dr Dimitrios Papaioannou (Ohio State University, Columbus, USA). Circular RNAs can sequester and inhibit specific microRNAs, and have been associated with leukemogenesis in AML.
Papaionnou: “We could demonstrate that a small subset of circular RNAs associate with clinical outcome of younger adults with CN-AML. High circular KLHL8 expression is an independent marker of longer disease-free and overall survival in this patient population. In a knock-down screening experiment we identified circFBXW7 as a putative regulator of the proliferative capacity of AML cells.”
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