Preceptorship program

08:30 – 09:00 Registration & Welcome 

09:00 – 09:15 Presentation of the preceptorship by the chairs and hosts

• Antonis Kattamis (Greece)
• Maria Dimopoulou (Greece)
• Mariane de Montalembert (France)
• Lucia de Francheschi (Italy)

09:15 – 10:15 Session 1: Advances in Hemoglobinopathy Biology: Genetics, Erythropoiesis and the Bone Marrow Niche

• Molecular Basis of thalassemia and genetic modifiers
  Cornelilis Hartveld (the Netherlands)
• Pathological erythropoiesis and BM niche (SCD and thalassemia related)
  Lucia de Francheschi (Italy)

10:15 – 10:30 Coffee break

10:30 – 11:30  Session 2: Organ Complications in Hemoglobinopathies: Underlying Pathophysiological Mechanisms

• Pathophysiology of thalassemia linked to organ complications
  Antonis Kattamis (Greece)
• Pathophysiology of SCD linked to organ complications
  David Rees (United Kingdom)

11:30 – 12:30 Session 3: Understanding NTDT: From Alpha Thalassemia to Phenoconversion

• NTDT with a focus on alpha thalassemia
  Pagona Flevari (Greece)
• Management of NTDT and phenoconversion
  Lucia de Francheschi (Italy)

12:30 – 13:30 Lunch break

13:30 – 15:30 Session 4: Optimizing Supportive Care in Thalassemia and Sickle Cell Disease

• Iron Chelation
  Antonis Kattamis (Greece)
• Transfusion strategies in hemoglobinopathies
  Yesim Aydinok (Türkiye)
• Alloimmunization and post-transfusion hemolysis in SCD: a clinical case
  France Pirenne (France)
• Pediatric care in hemoglobinopathies
  David Rees (United Kingdom)

15:30 – 15:45 Coffee break

15:45 – 17:15 Session 5: Case-Based Approaches to Organ Complications in Hemoglobinopathies

• How do you manage Thrombotic Complications in hemoglobinopathies
  Dimitris Farmakis (Greece)
• How do you manage Cardiac Complications in hemoglobinopathies
  Dimitris Farmakis (Greece)
• How do you manage liver disease in Patients with hemoglobinopathies
  Valeria Pinto (Italy)

17:15 – 18:00 Q&A Clossing session

19:30 – 21:30 Group dinner

08:30 – 10:00 Clinical case sharing part 1

10:00 – 10:15 Coffee break

10:15 – 11:15 Clinical cases from all groups

11:15 – 12:15 Session 6: Key imaging in hemoglobinopathies

• The contribution of MRI and liver elastography in Hemoglobinopathies
  Evangelos Alexiou (Greece)
• Brain imaging
  Evangelos Alexiou (Greece)

12:15 – 13:15 Lunch break

13:15 – 14:45 Session 7: Screening, Prenatal Diagnosis and Pregnancy in Thalassemia and Sickle Cell Disease

• Thalassemia and SCD Screening and Counseling Strategies
  Mariane de Montalembert (France)
• NGS in the diagnosis of hemoglobin, PGD (preimplantation diagnosis) and NIPT (non-invasive prenatal testing)
  Thessalia Papassava (Cyprus)
• Pregnancy in Thalassemia and SCD
  Maria Dimopoulou (Greece)

14:45 – 15:45 Session 8: Extramedullary Hematopoiesis and Aging-Related Challenges in Hemoglobinopathies

• Cancer risk / Age‑related complications
  Maria Dimopoulou (Greece)
• Extramedullary Hemopoiesis Diagnosis and Management
  Pagona Flevari (Greece)

15:45 – 16:00 Coffee break

16:00 – 17:30 Clinical case sharing part 2

17:30 – 18:00 Q&A session and closing of Day 2

08:30 – 10:00 Hands-on workshop “In the lab” (transfusion) and clinical tour

• Group 1:
  • First-level diagnostic tests for carrier screening and molecular Testing, PND and Genetic Counselling
    Maria Dimopoulou (Greece) Antonis Kattamis (Greece)
  • “In the lab” Transfusion and clinic tour + BMT
    Antonis Kattamis (Greece)
• Group 2: Patient therapeutic education
  Philippe Blasco (France)

(group rotation)

10:00 – 10:15 Coffee break

10:15 – 11:15 Session 9: New approved Drugs for hemoglobinopathies

• New approved Drugs for Thalassemia
  Maria Dimopoulou (Greece)
• New approved Drugs for SCD
  Mariane de Montalembert (France)

11:15 – 12:15 Session 10: Advances in Curative Therapies: From HSCT to Gene Editing

• HSCT
  Josu de la Fuente (United Kingdom)
• Gene Therapy and Gene Editing
  Josu de la Fuente (United Kingdom)

12:15 – 12:45 Faculty case sharing

12:45 – 13:00 Closing

13:00 – 13:30 Farewell lunch