Restoring Effective Anti-Tumor Response in Hodgkin Lymphoma with Nivolumab
Hodgkin Lymphoma typically affects young men and women in their 30s. Although it is highly curable with the current combination of chemo and radiation therapy, approximately 20% of patients will not be cured with first line regimens. Second line treatment typically involves different types of chemotherapy followed by a stem cell transplant. However, patients who are not cured with a stem cell transplant have a very poor prognosis. Accordingly, the development of new agents for patients with relapsed Hodgkin Lymphoma is of high priority. A few years ago, Brentuximab Vedotin was the first drug to be approved by the FDA for treatment of relapsed Hodgkin Lymphoma. In more than three decades, Nivolumab is the second drug that is now expected to be approved for this indication.”
The registrational trial, Checkmate 205, is a Phase 2 evaluating Nivolumab with classical Hodgkin lymphoma (cHL). Reported here are the results from one cohort: patients with cHL after failure of both ASCT and subsequent brentuximab vedotin treatment. The primary endpoint of objective response rate (ORR) per an independent radiologic review committee (IRRC) was 66.3% and 73% by investigator response (secondary endpoint). Median time to response was 2.1 months, and median duration of remission was 7.8 months (95% CI: 6.6-NE). The majority of responses (62.3%) were ongoing at the time of analysis. In patients who had no prior response to most recent prior brentuximab vedotin (n=43), nivolumab treatment resulted in an IRRC-assessed objective response rate of 72%. The safety profile of nivolumab was consistent with previously reported data in this tumor type.
Presenter: Dr Anas Younes
Affiliation: Memorial Sloan Kettering Cancer Center, New York City, United States
Topic: CHECKMATE 205: A PHASE 2 STUDY OF NIVOLUMAB IN PATIENTS WITH CLASSICAL HODGKIN LYMPHOMA FOLLOWING AUTOLOGOUS STEM CELL TRANSPLANTATION AND BRENTUXIMAB VEDOTIN
Abstract S793 will be presented by Anas Younes on Sunday, June 12, 2016, 08:00 - 08:15 in Hall A2.
About the EHA Annual Congress
Hematology is a specialty that covers everything to do with blood: its origin in the bone marrow, diseases of blood and their treatments. The latest data on research and developments will be presented. The topics range from stem cell physiology and development, to leukemia, lymphoma, myeloma - diagnosis and treatment; red blood cells -, white blood cells- and platelet disorders; thrombosis and bleeding disorders.
EHA Executive Office
Ineke van der Beek, Jon Tarifa
Mobile: +31(0)6 2011 1055