Postdoc position

07/30/22   France   INEM Institut Necker Enfants Malades, Paris  

Job description

Post-doctoral position to study the “Oncogenic deregulation of early human Lymphoid Lineage Specification”

If you are interested in the interface between leukemogenesis and the early stages of lymphopoiesis, this may be the job for you.

The Asnafi/Macintyre team “Normal and Pathological Differentiation” from the Institut Necker Enfants Malades research center (INSERM UMR1151) has teamed up with Bruno Canque’s team, combining expertise in oncogenesis and lymphopoiesis in order to dissect the transcriptional and epigenetic events underlying oncogenic arrest during early lymphoid specification of human hematopoietic stem cells. Joining this team will allow participation in a wide range of cellular and molecular approaches whereby understanding the malignant deregulation of early hemato-lymphopoiesis. Besides providing new insights into normal early lymphopoiesis, this project can help developing targeted and personalized therapeutics against acute leukemias of ambiguous lineage. The postdoctoral fellow will be co-supervised by V. Asnafi and B. Canque.

The successful candidate will be offered a 24-36 month contract with salary depending on experience. Applications for the above opening should include a full CV, a cover letter describing past and current projects, and the names of 2 references.

Requirements

Eligible applicants should be highly motivated and have a strong research interest in stem cell biology and leukemia research.

The applicant should have a PhD with significant laboratory experience in hematopoietic stem cell biology, multiparameter flow cytometry and cell sorting, lentiviral vector-mediated gene transduction and transcriptomics.

Applicant will be expected to be able to work in a collaborative environment and interact with basic and physician scientists.

How to apply

Applications should be jointly sent to: 

elizabeth.macintyre@aphp.fr 

vahid.asnafi@aphp.fr 

bruno.canque@ephe.psl.eu