SWG Educational Activities
1. EHA SWG EWALL Symposium at EHA 2022 Meeting, Vienna
Topic: MRD assessment in ALL. What is the best approach?
Chair: A Rijneveld
Speakers
- Use of MRD for therapeutic decisions in Ph-negative adult ALL. JM Ribera
- Next generation flow cytometry for MRD assessment. A Orfao
- MRD assessment in Ph+ ALL: PCR for Ig-TCR vs. BCR-ABL1. E Clappier
- NGS vs. flow cytometry: the MDACC experience. E Jabbour
2. Presentations at national and international meetings on behalf of the EHA-SWG EWALL
- 64TH ASH ANNUAL MEETING AND EXPOSITION. New Orleans, December 2022. Patrice Chevallier, Thibault Leguay, Rathana KIM, Marc Delord, Michael Doubek, Francoise Huguet, Aurelie Cabannes-Hamy, Ulla Wartiovaara-Kautto, Colombe Saillard, Emmanuel Raffoux, Thomas Cluzeau, Stephane Lepretre, Marie Balsat, Anna Berceanu, Nicolas Boissel, Claude Gardin, Emmanuelle Clappier, Herve Dombret, Philippe RousselotFractionated Inotuzumab Ozogamicin Combined with Low-Intensity Chemotherapy in Older Patients with Newly Diagnosed CD22+ Philadelphia Chromosome (Ph)-Negative B-Cell Precursor (BCP) Acute Lymphoblastic Leukemia (ALL): Results of the EWALL-INO Study. Blood (2022) 140 (Supplement 1): 6114–6116.
3. Clinical trials promoted by or involving the SWG
- EWALL-INO Study. Combined with Low-Intensity Chemotherapy in Older Patients with Newly Diagnosed CD22+ Philadelphia Chromosome (Ph)-Negative B-Cell Precursor (BCP) Acute Lymphoblastic Leukemia (ALL). Status: ongoing. Chaired by P Rousselot
- EWALL Ph03 trial. An open label, 3-arm, Randomised phase II study to Compare the Safety and Efficacy of Ponatinib in combination with either Chemotherapy or Blinatumomab with Imatinib plus Chemotherapy as front-line therapy for patients aged 55 years and over with Philadelphia chromosome positive (Ph+ or BCR-ABL+) acute lymphoblastic leukemia (ALL). Chaired by O Ottmann.
- ACCADEMIA trial for B-cell precursor ALL in adults (under development)
4. Collaborations on international projects promoted by or involving the SWG
- Development of an EWALL guideline for diagnosis and management of adult ALL (manuscript in preparation)
- Amir Enshaei, Melvin Joy, Ellie Butler, Amy Kirkwood, Monica Messina, Chiara Pavoni, Mireia Morgades, Christine Harrison, Robin Foa, Josep-Maria Ribera, Sabina Chiaretti, Renato Bassan, Adele Fielding, Anthony Moorman. A robust and validated integrated prognostic index for defining risk groups in adult acute lymphoblastic leukaemia: A European Working Group for Adult ALL (EWALL) collaborative study (manuscript submitted).
5. Grants received by SWG related networks or principal investigators
- Prognostic significance of IKZF1 (Ikaros) alterations in adult B-cell precursor acute lymphoblastic leukemia (HARMONY). PI: J Ribera
- Establishing European knowledge bank for evaluating risk factors in acute lmphoblastic leukaemia (HARMONY). PI: A Moorman and A Halstead