SWG Educational Activities

1. EHA SWG EWALL Symposium at EHA 2022 Meeting, Vienna

Topic: MRD assessment in ALL. What is the best approach?

Chair: A Rijneveld

Speakers

  • Use of MRD for therapeutic decisions in Ph-negative adult ALL. JM Ribera
  • Next generation flow cytometry for MRD assessment. A Orfao
  • MRD assessment in Ph+ ALL: PCR for Ig-TCR vs. BCR-ABL1. E Clappier
  • NGS vs. flow cytometry: the MDACC experience. E Jabbour

 2. Presentations at national and international meetings on behalf of the EHA-SWG EWALL

  • 64TH ASH ANNUAL MEETING AND EXPOSITION. New Orleans, December 2022. Patrice Chevallier, Thibault Leguay, Rathana KIM, Marc Delord, Michael Doubek, Francoise Huguet, Aurelie Cabannes-Hamy, Ulla Wartiovaara-Kautto, Colombe Saillard, Emmanuel Raffoux, Thomas Cluzeau, Stephane Lepretre, Marie Balsat, Anna Berceanu, Nicolas Boissel, Claude Gardin, Emmanuelle Clappier, Herve Dombret, Philippe RousselotFractionated Inotuzumab Ozogamicin Combined with Low-Intensity Chemotherapy in Older Patients with Newly Diagnosed CD22+ Philadelphia Chromosome (Ph)-Negative B-Cell Precursor (BCP) Acute Lymphoblastic Leukemia (ALL): Results of the EWALL-INO Study. Blood (2022) 140 (Supplement 1): 6114–6116.

 3. Clinical trials promoted by or involving the SWG

  • EWALL-INO Study. Combined with Low-Intensity Chemotherapy in Older Patients with Newly Diagnosed CD22+ Philadelphia Chromosome (Ph)-Negative B-Cell Precursor (BCP) Acute Lymphoblastic Leukemia (ALL). Status: ongoing. Chaired by P Rousselot
  • EWALL Ph03 trial. An open label, 3-arm, Randomised phase II study to Compare the Safety and Efficacy of Ponatinib in combination with either Chemotherapy or Blinatumomab with Imatinib plus Chemotherapy as front-line therapy for patients aged 55 years and over with Philadelphia chromosome positive (Ph+ or BCR-ABL+) acute lymphoblastic leukemia (ALL). Chaired by O Ottmann.
  • ACCADEMIA trial for B-cell precursor ALL in adults (under development)

 4. Collaborations on international projects promoted by or involving the SWG

  • Development of an EWALL guideline for diagnosis and management of adult ALL (manuscript in preparation)
  • Amir Enshaei, Melvin Joy, Ellie Butler, Amy Kirkwood, Monica Messina, Chiara Pavoni, Mireia Morgades, Christine Harrison, Robin Foa, Josep-Maria Ribera, Sabina Chiaretti, Renato Bassan, Adele Fielding, Anthony Moorman. A robust and validated integrated prognostic index for defining risk groups in adult acute lymphoblastic leukaemia: A European Working Group for Adult ALL (EWALL) collaborative study (manuscript submitted).

5. Grants received by SWG related networks or principal investigators

  • Prognostic significance of IKZF1 (Ikaros) alterations in adult B-cell precursor acute lymphoblastic leukemia (HARMONY). PI: J Ribera
  • Establishing European knowledge bank for evaluating risk factors in acute lmphoblastic leukaemia (HARMONY). PI: A Moorman and A Halstead