Decoding CLL Immunogenetics: A Global Study to Refine Disease Biology and Patient Stratification (SWG on European Research Initiative on CLL (ERIC))

Project Lead

Andreas Agathangelidis
Assistant Professor, Department of Biology, School of Science, National and Kapodistrian University of Athens, Athens, Greece

Project Team

Karla Plevova
Assistant Professor, Faculty of Medicine, Masaryk University, Brno, Czech Republic
Csaba Bödör
Professor, Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
Krzysztof Giannopoulos
Professor, Department of Experimental Haematooncology, Medical University of Lublin, Lublin, Poland
Helena Podgornik
Principal Investigator, Lubljana University Medical Center, Lubljana, Slovenia

Project Background and Aims

This project aims to refine the biological and clinical classification of chronic lymphocytic leukemia (CLL) by systematically characterizing stereotyped B-cell receptor immunoglobulin (BcR IG) subsets across a large pan-European cohort.

By leveraging the collaborative strength of the European Research Initiative on CLL (ERIC), we will harmonize immunogenetic and clinical data from more than 90,000 patients to better understand disease heterogeneity and its relationship to treatment outcomes in the era of targeted therapies.

Support from the EHA SWG grant is essential to enable centralized data harmonization, standardized bioinformatic analyses, and secure integration of clinical information. This funding transforms distributed datasets into a unified European resource, delivering rapid, high-impact results while laying the groundwork for future large-scale collaborative funding and advancing precision medicine in CLL.

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