2024 winners

Topic: Improving the diagnosis and management of smoldering multiple myeloma using analyses of peripheral blood University of Iceland Iceland

Topic: Endothelial cell plasticity as a therapeutic target in acute myeloid leukemia Cochin Institute France

Topic: Optimizing combination treatment of targeted agents and T-cell engagers in CLL, a metabolic approach Amsterdam University Medical Center The Netherlands

Topic: Towards more effective nucleoside analogue treatment of acute lymphoblastic leukemia Karolinska Institutet Sweden

Topic: The FoxO1-GAB1 axis regulates the microenvironmental interactions of AML cells CEITEC Masaryk University Czechia

Topic: Unravelling the functional role and therapeutic potential of transcription factors in chronic lymphocytic leukemia Consorci d'Investigacions Biomèdiques August Pi I Sunyer Spain

Topic: Studying clonal complexity and functional properties of long-term engrafted human Hematopoietic Stem/Progenitor Cells after gene therapy Ospedale San Raffaele S.R.L. Italy

Topic: Drivers of secondary acute myeloid leukemia: internalizing the external Erasmus University Medical Center The Netherlands

Topic: Predictive modelling based on tracking clonal evolution in childhood leukaemia as a tool understand the biology of treatment resistance and guide the design of new therapeutic protocols Lund University Sweden

Topic: Role of monosomy 7 in venetoclax resistance in acute myeloid leukaemia Amsterdam UMC The Netherlands

Topic: MACROCAR: Contribution of lymph node macrophages to CAR T cells resistance Institut Gustave Roussy France

Topic: Characterisation and targeting of disordered B lineage progenitor states in CREBBP-mutated B cell acute lymphoblastic leukaemia University of Cambridge United Kingdom

Topic: Investigating the role of iron in TET2 clonal hematopoiesis Instituto de Biologia Molecular e Celular Portugal

Topic: Unleashing the force of the tumor microenvironment through immunomodulatory therapies in follicular lymphoma Leiden University Medical Center The Netherlands

Topic: Understanding the role of macrophages at single cell level in sickle cell related pulmonary hypertension University of Verona Italy

Topic: The role of cholinergic signaling on immune cell metabolism, acute graft-versus-host disease pathogenesis and graft-versus-tumour effect University of Cambridge United Kingdom

Topic: The role of cholinergic signaling on immune cell metabolism, acute graft-versus-host disease pathogenesis and graft-versus-tumour effect Basel University Hospital Switzerland

Topic: Decoding the Role of the Noncoding Genome in Diffuse Large B-Cell Lymphoma (noncoDLBCL) Charité, University Medicine Berlin Germany

Topic: Decoding the Role of the Noncoding Genome in Diffuse Large B-Cell Lymphoma (noncoDLBCL) Josep Carreras Leukaemia Research Institute Spain

Topic: Dissecting the role of PIEZO1 in liver sinusoidal endothelial cells to identify new druggable targets for iron overload Università degli Studi di Napoli Federico II Italy

Topic: Dissecting the role of PIEZO1 in liver sinusoidal endothelial cells to identify new druggable targets for iron overload University of Heidelberg, Heidelberg Germany

Topic: Identification of MSI2 direct targets in KMT2A-rearranged infant Acute Lymphoblastic Leukemia through HyperTRIBE system Fondazione IRCCS, San Gerardo dei Tintori Italy

Topic: Immune responses after CALR targeted therapies Institut Paoli Calmette - Aix Marseille University France

Topic: Studying the Role of Bone Marrow Niche in GATA2 Deficiency (BMN-G2D) Fundació Institut d’Investigació Biomèdica de Bellvitge – IDIBEL Spain

Topic: Single cell whole genome interrogation of relapsed/refractory multiple myeloma patients after anti-BCMA CAR T cell ARI0002h therapy Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS) Spain

Topic: Evaluating the application of cfDNA analysis in studying the pathogenesis of pediatric PTLDs Charles University Czechia

Topic: High-throughput miRNA functional screening to identify regulators predictive of response to novel treatment in relapsed/refractory diffuse large B-cell lymphoma patients IRCCS Regina Elena National Cancer Institute and “Sapienza” University Italy

Topic: Epigenetic regulation of CD123 Charles University Czechia

Topic: Investigating the role of CMTR1 in erythrocytosis using iPSCs Institute of Molecular Genetics of the Czech Academy of Sciences Czechia

Topic: Characterization of RNA-binding proteins in acute myeloid leukemia driven by the KMT2A-MLLT3 fusion oncogene University of Basel Switzerland

Topic: Unraveling Mechanisms of Response in CAR T-Cell Therapy in T Cell Lymphomas: A Single-Cell RNAseq Approach Hospital General Universitario Gregorio Marañón Spain

Topic: Leveraging mechanical forces for gene therapies University Health Network, University of Toronto Canada

Topic: Optical imaging of Weibel-Palade body exocytosis in patient-derived endothelial cells to unravel the impact of pathogenic MADD mutations on Von Willebrand factor secretion Erasmus Medical Center The Netherlands

Topic: The role of CXCR4 in synchronised erythropoiesis of human pluripotent stem cells Institute of Cell Biology and Immunology Thurgau Switzerland

Topic: Testing of GSH metabolism perturbations as a leukemia treatment strategy. First Faculty of Medicine, Charles University Czechia

Topic: Optimising therapies targeting fatty acid desaturation in AML Barts Cancer Institute, Queen Mary University of London United Kingdom

Topic: Optimising therapies targeting fatty acid desaturation in AML Cancer Research Institute of Montpellier France

Topic: Optimising therapies targeting fatty acid desaturation in AML University of Zagreb Croatia

Topic: The International Integrative Innovative Immunology for MDS (i4MDS) King's College London United Kingdom

Topic: The International Integrative Innovative Immunology for MDS (i4MDS) Leipzig University Germany

Topic: The International Integrative Innovative Immunology for MDS (i4MDS) MLL Labs Germany

Topic: The International Integrative Innovative Immunology for MDS (i4MDS) Hospital de Luz Lisboa Portugal

Topic: Large-Scale Screening of Myeloid Neoplastic Precursor States using Blood Cell Morphology (MorphoSCREEN) Helsinki University Hospital Finland

Topic: Large-Scale Screening of Myeloid Neoplastic Precursor States using Blood Cell Morphology (MorphoSCREEN) Karolinska Insitutet Sweden

Topic: Large-Scale Screening of Myeloid Neoplastic Precursor States using Blood Cell Morphology (MorphoSCREEN) Dubrava University Hospital Croatia

Topic: Large-Scale Screening of Myeloid Neoplastic Precursor States using Blood Cell Morphology (MorphoSCREEN) Munich Leukemia Laboratory Germany

Topic: Exploring a novel chromatin-related dependency of AML initiation University of Basel Switzerland

Topic: Unraveling the interactome of STAT3 isoforms in acute myeloid leukemia Karl Landsteiner University of Health Sciences Austria

Topic: A nutrition-immunity axis mediating conventional dendritic cell development in the bone marrow The Champalimaud Centre for the Unknown Portugal

Topic: Decoding immune suppressive networks driving clonal progression in CLL Antwerp University Hospital Belgium

Topic: Kicking-off the clonal heterogeneity of Acute Myeloid leukemia with monocytic phenotype German Cancer Research Center Germany

Topic: Unraveling the role of kielin/chordin-like protein KCP as a novel activator of the BMP-SMAD pathway and hepcidin in hepatocytes Ospedale San Raffaele Italy

Topic: Deciphering the crosstalk between BM niche and hematopoietic stem cells in GATA2 deficiency IDIBELL (Bellvitge Biomedical Research Institute) Spain

Topic: Revealing metabolites modulating immunosuppression in AML-TME #ReveAL Josep Carreras Leukaemia Research Institute Spain

Topic: Transfer RNA (tRNA) perturbations regulate hematopoietic differentiation and malignancy Goethe University Hospital Frankfurt Germany

Topic: Sucnr1 in the mesenchymal-adipocytic lineage of the HSC niche (MAdSuc) University of Oslo Norway

Topic: Elucidate the role of IRE1α in inflammatory driven clonal hematopoiesis Université de Rennes France