Meeting program

13:00–13:15 Opening and welcome

13:15–15:15 Session 1: HSC ageing

Lectures

• Immuno-ageing
  Claudia Waskow (Germany)
• Metabolic reprogramming aged HSCs
  Nicola Vannini (Switzerland)

Oral presentations

• (7054488) Heterogeneity in hematologic aging is driven by stochasticity
  Yiwen Zhang (Germany)
• (7041062) Clonal tracing with somatic epimutations reveals dynamics of blood ageing
  Lars Velten (Spain)
• (7059096) Integrated analysis of aging human hematopoietic stem cells reveals an expanding subset enriched for signatures of quiescence and inflammation
  Peter van Galen (United States)
• (7055153) Changes in glutamine metabolism drive haematopoietic stem cell ageing
  Charlotte Hellmich (United Kingdom)

Oral flash talks

• (7055393) Defining the impact of ageing on haematopoiesis through integrated molecular and functional single-cell analyses
  Nieves Garcia-Gisbert (United Kingdom)
• (7054194) Uncovering cell type-specific DNA replication dynamics and stress during hematopoiesis using SCREAM-seq
  Cansu Koyunlar (The Netherlands)
• (7055131) C/ebpδ preserves hematopoietic stem cell homeostasis and regulates myeloid commitment in a context-dependent manner
  Irina Ribeiro Bas (Czechia)
• (7053505) Targeting rhoa activity rejuvenates aged hematopoietic stem cells
  Eva Mejia-Ramirez (Spain)

15:15–15:45 Coffee break

15:45–17:15 Workshop 1: Strategies to prevent, delay or reverse ageing

Lectures

• Experimental clonal tracing in ageing
  Alejo Rodriguez-Fraticelli (Spain)
• Extrinsic factors regulating HSC aging and opportunities for intervention
  Maria Carolina Florian (Spain)

Oral presentations

• (7041070) Partial and transient reprogramming in vivo prevents hematopoietic stem cell aging by acting on heterochromatin erosion and retrotransposon expression
  Audrey Porquet (France)
• (7054146) Enhancing hematopoietic stem cell mobilization in aging mice via electrical sympathetic neuromodulation
  Ya-Ting Hsu (Taiwan)

17:15–18:00 Welcome Reception

09:00–10:00 Session 2: Senescence

• Cellular senescence in ionizing radiation (IR) and chemotherapy induced normal tissue damage
  Daohong Zhou (United States)
• Senescence in myeloid malignancies and HSCs
  Raffaella Di Micco (Italy)
• Lecture title to be announced
  Adele Fielding (United Kingdom)

10:00–10:15 Coffee break

10:15–11:30 Workshop 2: Clinical opportunities of senolytics in hemato-oncology

• Senescence in cancer
  Manuel Collado (Spain)
• Therapeutic opportunities for senescence in lymphoma or other cancers
  Clemens Schmitt (Germany)
• Panel discussion
  All speakers

11:30–11:45 Coffee break

11:45–13:00 Workshop 3: Extrinsic factors (niche)

Lectures

• Ageing of the BM microenvironment
  Cesar Nombela-Arrieta (Switzerland)

Oral presentations

• (7054553) Chronic inflammation drives hsc aging, clonal expansion, and altered infection response in mice
  Srdjan Grusanovic (Czechia)
• (7059002) Disrupted harmony: early inflammatory remodeling of the bone marrow niche in clonal hematopoiesis and myelodysplastic syndromes
  Borhane Guezguez (Germany)

Oral flash talks

• (7051372) A notch trans-activation to cis-inhibition switch underlies hematopoietic stem cell aging
  Francesca Matteini (Spain)
• (7055144) Dissecting stroma-mediated regulation of hematopoietic lineage output: a high-throughput in vitro platform to model age- and disease-associated niche remodeling
  Jonas Rauchhaus (Germany)
• (7059611) Modified cytokines as a new tool to direct hematopoietic stem cell fate
  Maorong Xie (United Kingdom)
• (7059000) Single-cell profiling of the bone marrow niche in tp53-aml patients reveals age-associated cell-cell interaction remodelling
  Rebecca Andersson (Spain)
• (7055111) Dissecting the interactions between leukemic cells and the aging bone marrow niche
  Alba Ferrer-Pérez (Spain)
• (7055360) Human mesenchymal stromal cells in <I>Dnmt3a<|I>mut clonal hematopoiesis instruct healthy hematopoietic stem|progenitor cells toward an aging phenotype in a clone size dependent manner
  Anna Navarro Figueredo (Germany)
• (7055284) Central obesity is associated with accelerated dynamics of Dnmt3a-mutant clonal hematopoiesis
  Miriam Díez-Díez (Spain)
• (7054262) Chemical partial reprogramming ameliorates age-associated detrimental features on the hematopoietic bone marrow niche
  Patricia Marqués González (Sweden)

13:00–14:00 Coffee break

14:00–15:30 Workshop 4: Challenges and recommendations for the translation of biomarkers of ageing

• Epigenetic aging and adverse effects in UK based populations
  Riccardo Marioni (United Kingdom)
• Validation of ageing biomarkers
  Chiara Herzog (United Kingdom)
• Disentangling the reasons why older adults do not readily participate in cancer trials: a socio-epidemiological mixed methods approach
  Claudio Cerchione (Italy)
• Panel discussion
  All speakers

15:30–15:45 Coffee break

15:45–17:15 Session 5: Clinical trials

Lectures

• Artificial Intelligence to generate synthetic patient cohorts to serve as control groups in virtual clinical trials
  Alfonso Piciocchi (Italy)
• Interventions/Clinical trials in CH
  Kirsten Grønbæk (Denmark)

Oral presentations

• (7054869) Clonal hematopoiesis in follicular lymphoma: analysis of the phase III fil foll12 trial
  Maher Nawar (Italy)

• (7053498) Episodes of emergency myelopoiesis increase tet2-derived clonal haematopoiesis via cell-intrinsic resistance of mutant stem cells and exacerbated inflammatory response of myeloid progeny
  Hector Huerga Encabo (United Kingdom)
• (7048157) Clinical progression of clonal hematopoiesis is determined by a combination of mutation timing, fitness, and clonal structure
  Eric Latorre Crespo (Spain)
• (7030593) Clonal haematopoiesis burden can be measured through dna methylation
  Sam Crofts (United Kingdom)

10:30–10:45 Coffee break

10:45–12:45 Workshop 6: CHIP in the pre-clinical and clinical models

Lectures

• The aging of the blood system and leukemia diagnosis from the peripheral blood
  Liran Shlush (Israel)
• CHIP, hematology and cardiovascular disease
  Jose Javier Fuster (Spain)

Oral presentations

• (7055287) Divergent effects of tet2- and dnmt3a-mutant clonal hematopoiesis on breast cancer progression upon aging
  Francisco Caiado (Switzerland)
• (7054420) <I>Tet2<|I> clonal hematopoiesis as a mechanistic driver of diet-induced liver cancer
  Lina Merg (Germany)
• (7041068) Differential sensitivity to chronic inflammation-induced loss of heterochromatin, transposable element expression and dna damage contributes to the expansion of tet2-deficient cells
  Emilie Elvira-Matelot (France)

Oral flash talks