Meeting program
13:00–13:15 Opening and welcome
13:15–15:00 Session 1: Platelet Disorders: Pathophysiology
Chairs: Paolo Gresele (Italy) & Andreas Greinacher (Germany)
Lectures
- Inherited platelet disorder: Clinical and pathophysiological update
Loredana Bury (Italy) & Paolo Gresele (Italy) - Novel insights in the pathogenesis of ITP
John Semple (Sweden) - Prothrombotic platelet disorders (TTP, HIT, VITT)
Andreas Greinacher (Germany)
Poster talk presentations
- INHERITED PLATELET GPIV DEFICIENCY: FIRST DESCRIPTION OF TWO PATIENTS WITH BLEEDING DIATHESIS
Loredana Bury (Italy) - AUTOSOMAL DOMINANT MACROTHROMBOCYTOPENIA WITH ITGA2B AND ITGB3 VARIANTS: CLINICAL, FUNCTIONAL, AND STRUCTURAL INSIGHTS FROM A LARGE COHORT
Miguel Oliveira (Portugal) - IMMUNOPHENOTYPIC CHARACTERIZATION OF MYELOID SUPPRESSOR CELLS IN PATIENTS WITH AUTOIMMUNE THROMBOPENIA
Vasileia Kaliafenta (Greece)
15:00–15:30 Coffee break
15:30–17:15 Session 2: Coagulation Disorders: Pathophysiology
Chairs: Giancarlo Castaman (Italy) & Peter Lenting (France)
Lectures
- The pathophysiology of von Willebrand Disease
Peter Lenting (France) - Novel molecular mechanisms of the pathophysiology of hemophilia
Mirko Pinotti (Italy) - Bleeding disorders and the vascular wall: a complex cross-talk
Anna Randi (United Kingdom)
Poster talk presentations
- A NOVEL HISTONE-NANOFIBER DRESSING (HIST-CEL) FOR RAPID HAEMOSTATIC CONTROL IN TRAUMA
Jun Yong (United Kingdom) - INHIBITORS IN NON-SEVERE HEMOPHILIA A: AN UNDERESTIMATED ISSUE
Silvia Linari (Italy) - THALIDOMIDE FOR RECURRENT GASTROINTESTINAL BLEEDING IN RARE BLEEDING DISORDERS AND VENOUS MALFORMATIONS: A MONOCENTRIC EXPERIENCE
Speaker to be announced
17:15–18:45 Session 3: Round table: Rare bleeding disorders registries
Chairs: Mar Mañú Pereira (Spain) & Jose Rivera (Spain)
- The ITP Natural History Study Registry
Michele Lambert (United States) - The Italian Registry of inherited platelet function disorders
Erica De Candia (Italy) - EuroBloodNet
Mar Mañú Pereira (Spain) - European Registry of platelet disorders
Jose Rivera (Spain) - Panel discussion
All speakers
18:45–19:30 Poster session and welcome reception
09:00–10:30 Session 4: The laboratory of bleeding disorders (I)
Chairs: James O’Donnell (Ireland) & Kathleen Freson (Belgium)
- The laboratory of hemophilia and the monitoring of the new drugs
Peter Lenting (France) - How laboratory can help in understanding the pathophysiology of von Willebrand disease
James O’ Donnel (Ireland) - The impact of next generation sequencing in the diagnosis of bleeding disorders
Kathleen Freson (Belgium)
10:30–11:00 Coffee break
11:00–12:30 Session 5: The laboratory of bleeding disorders (II)
Chairs: Andreas Greinacher (Germany) & Donald Arnold (Canada)
- ITP, a challenging diagnosis
Donald Arnold (Canada) - Clinical and laboratory diagnosis of thrombotic thrombocytopenias: an integrated approach
Marie Scully (United Kingdom) - The laboratory diagnosis of platelet disorders
Jose Rivera (Spain)
12:30–13:30 Lunch break
13:00–13:30 Satellite Symposium
13:30–14:45 Oral session: Coagulation
Chair to be announced
- DECIPHERING BLEEDING DIATHESIS OF NEWLY DIAGNOSED AML WITH APL-LIKE PHENOTYPE: IMPLICATION OF EASIX-BASED RISK STRATIFICATION IN VENETOCLAX ERA
Mingkai Shu (China) - MACHINE LEARNING FOR THE PREDICTION OF BLEEDING DISORDER OF UNKNOWN CAUSE DIAGNOSIS
Tim Dreier (Austria) - HIGH PREVALENCE OF BLEEDING DISORDER OF UNKNOWN CAUSE IN WOMEN: FINDINGS FROM THE MAASTRICHT BLEEDING COHORT
Nienke Meskes (Netherlands) - CAN DUAL TARGETING OF FXII AND GAS6 PREVENT THROMBOSIS WITH NO RISKS OF BLEEDING
Mariantonietta Tripodo (Switzerland) - MULTICENTRE REAL-WORLD EXPERIENCE OF EMICIZUMAB PROPHYLAXIS IN AN ITALIAN COHORT OF 49 CHILDREN WITH SEVERE HEMOPHILIA A – EMIPED STUDY
Lisa Pieri (Italy) - DIAGNOSTIC VALUE OF THROMBIN GENERATION USING DIFFERENT TRIGGER REAGENTS IN PATIENTS WITH BLEEDING DISORDER OF UNKNOWN CAUSE
Amaury Monard (Netherlands)
14:45–16:15 Session 6: Rare coagulation disorders
Chair: Giancarlo Castaman (Italy)
- Rare inherited coagulation disorders: an update
Yesim Dargaud (France) - How to investigate bleeding disorders of unknown cause, clinical and laboratory diagnosis
Johanna Gebhart (Austria) - Management of rare coaugulation disorders
Giancarlo Castaman (Italy)
16:15–16:45 Coffee break
16:45–18:15 Session 7: Real life problems
Chair to be announced
- Patient reported outcome in hemophilia and inherited bleeding disorders: Matching only clinical endpoints?
Karin Fijnvandraat (Netherlands) - The patient point of view
Enrico Ferri Grazzi (Italy) - The clinician point of view
Andrea Artoni (Italy) - The regulatory agencies point of view
Antonella Isgrò (Italy) - Panel discussion
All speakers
08:30–10:00 Session 8: Treatment of bleeding disorders (I)
Chairs: Francesco Rodeghiero (Italy) & Roger Schutgens (Netherlands)
- Current and innovative therapies for immune thrombocytopenia
Francesco Rodeghiero (Italy) - Management of angiodysplasia and gastrointestinal bleeding in congenital bleeding disorders
Sophie Susen (France) - Efficacy and safety of platelet transfusions for treatment of inherited platelet disorders
Roger Schutgens (Netherlands)
10:00–10:30 Coffee break
10:30–11:45 Oral Session: Platelets
Chair to be announced
- RECOGNIZING INHERITED PLATELET DISORDERS USING IMMUNOFLUORESCENCE MICROSCOPY ON THE PERIPHERAL BLOOD SMEAR: AN INTERLABORATORY WORKSHOP
Carlo Zaninetti (Germany) - DIAGNOSTIC VALUE OF THE ASSESSMENT OF PLATELET GRANULE CONTENT AND RELEASE IN PATIENTS WITH INHERITED PLATELET FUNCTION DISORDERS (IPFD) AND NORMAL PLATELET AGGREGATION
Eleonora Petito (Italy) - IMMOBILIZED IGG-CONTAINING IMMUNE COMPLEXES REQUIRE PLATELETS TO RECRUIT NEUTROPHILS DURING INFLAMMATION
Eric Boilard (Canada) - PLATELET LIPIDOMIC ALTERATIONS IN PATIENTS WITH UNEXPLAINED BLEEDING AND PLATELET DYSFUNCTION
Dino Mehic (Austria) - PLATELET DYSFUNCTION IN NOONAN SYNDROME PATIENTS
Silvia Sorrentino (Italy) - ENHANCING HEMOSTASIS IN GLANZMANN THROMBASTHENIA VIA PROTEIN S INHIBITION
Rim Diab (Switzerland)
11:45–13:15 Session 9: Treatment of bleeding disorders (II)
Chairs: Paolo Gresele (Italy) & Giancarlo Castaman (Italy)
- Gene therapy in hemophilia: Benefits and limits
Wolfgang Miesbach (Germany) - Use of recombinant ADAMTS13 for treatment of thrombotic microangiopathies
Marie Scully (United Kingdom) - Innovative treatments for platelet function disorders
Suthesh Sivapalaratnam (United Kingdom)
13:15 Takeaways and closing