Meeting program
13:00–13:30 Opening and welcome
13:30–15:00 Session 1: Platelet Disorders: Pathophysiology
Chairs: Paolo Gresele (Italy) & Andreas Greinacher (Germany)
- Inherited platelet disorder: Clinical and pathophysiological update
Loredana Bury (Italy) & Paolo Gresele (Italy) - Novel insights in the pathogenesis of ITP
John Semple (Sweden) - Prothrombotic platelet disorders (TTP, HIT, VITT)
Andreas Greinacher (Germany)
15:00–15:30 Coffee break
15:30–17:00 Session 2: Coagulation Disorders: Pathophysiology
Chairs: Giancarlo Castaman (Italy) & Peter Lenting (France)
- The pathophysiology of von Willebrand Disease
Peter Lenting (France) - Novel molecular mechanisms of the pathophysiology of hemophilia
Mirko Pinotti (Italy) - Bleeding disorders and the vascular wall: a complex cross-talk
Anna Randi (United Kingdom)
17:00–18:30 Session 3: Round table: Rare bleeding disorders registries
Chairs: Mañú Mar Pereira (Spain) & Jose Rivera (Spain)
- The ITP Natural History Study Registry
Michele Lambert (United States) - The Italian Registry of inherited platelet function disorders
Erica De Candia (Italy) - EuroBloodNet
Mañú Mar Pereira (Spain) - European Registry of platelet disorders
Jose Rivera (Spain) - Panel discussion
All speakers
18:30–19:30 Poster session and welcome reception
09:00–10:30 Session 4: The laboratory of bleeding disorders (I)
Chairs: James O’Donnell (Ireland) & Kathleen Freson (Belgium)
- The laboratory of hemophilia and the monitoring of the new drugs
Peter Lenting (France) - How laboratory can help in understanding the pathophysiology of von Willebrand disease
James O’ Donnel (Ireland) - The impact of next generation sequencing in the diagnosis of bleeding disorders
Kathleen Freson (Belgium)
10:30–11:00 Coffee break
11:00–12:30 Session 5: The laboratory of bleeding disorders (II)
Chairs: Andreas Greinacher (Germany) & Donald Arnold (Canada)
- ITP, a challenging diagnosis
Donald Arnold (Canada) - Clinical and laboratory diagnosis of thrombotic thrombocytopenias: an integrated approach
Marie Scully (United Kingdom) - The laboratory diagnosis of platelet disorders
Jose Rivera (Spain)
12:30–13:30 Lunch break
13:30–14:30 Oral session
14:30–16:00 Session 6: Rare coagulation disorders
Chair: Giancarlo Castaman (Italy)
- Rare inherited coagulation disorders: an update
Yesim Dargaud (France) - How to investigate bleeding disorders of unknown cause, clinical and laboratory diagnosis
Johanna Gebhart (Austria) - Management of rare coaugulation disorders
Giancarlo Castaman (Italy)
16:00–16:30 Coffee break
16:30–17:30 Satellite Symposium
17:30–19:00 Session 7: Real life problems
Chair to be announced
- Patient reported outcome in hemophilia and inherited bleeding disorders: Matching only clinical endpoints?
Karin Fijnvandraat (The Netherlands) - The patient point of view
Enrico Ferri Grazzi (Italy) - The clinician point of view
Andrea Artoni (Italy) - The regulatory agencies point of view
Enrico Costa (Italy) - Panel discussion
All speakers
08:30–10:00 Session 8: Treatment of bleeding disorders (I)
Chairs: Francesco Rodeghiero (Italy) & Roger Schutgens (The Netherlands)
- Innovative therapies for immune thrombocytopenia
Francesco Rodeghiero (Italy) - Management of angiodysplasia and gastrointestinal bleeding in congenital bleeding disorders
Sophie Susen (France) - Efficacy and safety of platelet transfusions for treatment of inherited platelet disorders
Roger Schutgens (The Netherlands)
10:00–10:30 Coffee break
10:30–11:30 Oral Session
11:30–13:00 Session 9: Treatment of bleeding disorders (II)
Chairs: Paolo Gresele (Italy) & Giancarlo Castaman (Italy)
- Gene therapy in hemophilia: Benefits and limits
Wolfgang Miesbach (Germany) - Use of recombinant ADAMTS13 for treatment of thrombotic microangiopathies
Marie Scully (United Kingdom) - Innovative treatments for platelet function disorders
Suthesh Sivapalaratnam (United Kingdom)
13:00–13:30 Takeaways and closing