Meeting program

14:00–14:30 Opening and welcome

  • Organizing Committee

14:30–16:00 Session 1a–Clonal dynamics during development and aging

  • Lecture
    Adam MacLean (United States)
  • Lecture
    Michael Spencer Chapman (United Kingdom)
  • Lecture
    Jennifer Trowbridge (United States)

16:00–16:30 Coffee break

16:30–17:15 Session 1b–Clonal dynamics during development and aging

  • Dormant Hematopoietic Stem Cells are established During Embryonic Development: a process regulated by Notch
    Patricia Herrero Molinero (Spain)
  • Biological properties and clonality of engineered hematopoietic stem|progenitor cells persisting long-term after gene therapy
    Pamela Quaranta (Italy)
  • Hematologic aging heterogeneity arises mainly from stochastic processes, not from genetic or environmental variation
    Charles Dussiau (Germany)

17:15–18:00 Opening keynote

  • Hanna Mikkola (United States)

18:00–18:30 Poster pitch 1

  • Pitch presenters to be confirmed

18:30–20:00 Poster walk with reception

20:30–22:00 Dinner

08:45–10:15 Session 2a–Inherited predispositions for early and late onset hematologic disease

  • Lecture
    Alessandra Giorgetti (Spain)
  • Lecture
    Jean Soulier (France)
  • Lecture
    Julia Skokowa (Germany)

10:15–11:00 Session 2b–Inherited predispositions for early and late onset hematologic disease

  • Developmental-Specific Lineage Plasticity Within the Hematopoietic Stem and Progenitor Compartment is Encoded at the Chromatin Level
    Sara Palo (Sweden)
  • A new mouse model of JMML highlights differential susceptibility of embryonic HSPCs to KrasG12D and identifies inflammation as a targetable therapeutic axis
    Emanuele Azzoni (Italy)
  • Cohesin mutations lead to downregulation of HLA Class II gene expression, providing a mechanism for leukemic progression in Down syndrome and adult AML
    John Crispino (United States)

11:00–11:30 Coffee break & poster browsing

11:30–12:15 HemaSphere session

  • Speaker to be confirmed

12:15–13:00 Data visualization in publishing

  • Isabel Romero Calvo (Spain)

13:00–14:00 Lunch break

14:00–15:30 Session 3a–Immune dysfunction in early, intermediate and later life

  • Lecture
    Claudia Waskow (Germany)
  • Lecture
    Samuele Ferrari (Italy)
  • Lecture
    Francesca Fioredda (Italy)

15:30–16:00 Poster pitch 2

  • Pitch presenters to be confirmed

16:00–16:45 Coffee break & poster browsing

16:45–17:30 Session 3b–Immune dysfunction in early, intermediate and later life

  • TET2-mutant clonal hematopoiesis enhances NAFLD-associated HCC through dysregulated T cells
    Lina Merg (Germany)
  • DNMT3A-R882 mutation intrinsically drives maladaptive neutropoiesis from human haematopoietic stem cells
    Giovanna Mantica (United Kingdom)
  • Conserved tertiary lymphoid structures emerge in aged bone marrow across acute myeloid leukaemia and multiple myeloma
    Simona Voletta (United Kingdom)

17:30–18:30 YEHA panel discussion

  • Katherine Bridge (United Kingdom)
  • Rhiannon Newman (Finland)

18:30–20:00 Poster walk with reception

20:30–22:00 Dinner

08:45–10:15 Session 4a–Stress hematopoiesis (inc. inflammation): from hematopoietic specification through to old age

  • Lecture
    Cristina Lo Celso (United Kingdom)
  • Lecture
    Raquel Espin-Palazon (United States)
  • Lecture
    Françoise Porteu (France)

10:15–11:00 Session 4b–Stress hematopoiesis (inc. inflammation): from hematopoietic specification through to old age

  • Clonal hematopoiesis increase after episodes of emergency myelopoiesis via cell-intrinsic resistance of mutant stem cells and hyperactivated myeloid progeny
    Hector Huerga Encabo (United Kingdom)
  • The stress-associated nuclear protein 1 (Nupr1) primes hematopoietic stem cells to hyperactive, non-canonical megakaryocyte progenitor differentiation during aging
    Arthur Svendsen (Netherlands)
  • Determining the contribution of the bone marrow microenvironment to venetoclax and azacitidine therapy resistance in AML
    Steven Ngo (United Kingdom)

11:00–11:45 Coffee break

11:45–13:15 Session 5a–Age-dependent roles of the hematologic microenvironment

  • Lecture
    Catherine Robin (Netherlands)
  • Lecture
    Beth Psaila (United Kingdom)
  • Lecture
    Olaia Naveiras (Switzerland)

13:15–14:00 Lunch break

14:30–22:00 Activity with dinner

08:30–09:15 Session 5b–Age-dependent roles of the hematologic microenvironment

  • Mass Spectrometry-based Profiling of Bone Marrow Niche Secretome Remodeling in Aging and Tet2-mutant Clonal Hematopoiesis
    Maria Jassinskaja (Sweden)
  • Dissecting the interactions between leukemic cells and the aging bone marrow niche
    Alba Ferrer-Pérez (Spain)
  • The Ntn-1|Neo-1 axis regulates adhesion and differentiation of aging HSCs.
    Krzysztof Szade (Poland)

09:15–10:45 Session 6a–Hematologic malignancies: from childhood through to old age

  • Lecture
    Katrin Ottersbach (United Kingdom)
  • Lecture
    Florian Perner (Germany)
  • Lecture
    Andrew Weng (Canada)

10:45–11:15 Coffee break

11:15–12:00 Session 6b–Hematologic malignancies: from childhood through to old age

  • Identifying a novel leukaemia-associated macrophage population in KMT2A-MLLT3 infant leukaemia as a potential candidate for immunotherapy
    Hollie Vaughan (United Kingdom)
  • CXCR4 blockade suppresses progression of primary T-cell acute lymphoblastic leukemia
    Mark Gower (Canada)
  • Multi-omics single-cell spatial profiling of the bone marrow in pediatric and adult acute myeloid leukemia uncovers immunosuppressive microenvironmental interactions
    Merel van der Meulen (Netherlands)

12:00–12:45 Closing keynote

  • Coleman Lindsley (United States)

12:45–13:15 Closing ceremony and awards

  • Organizing Committee

13:15–14:00 Farewell lunch and departure

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