13:30 - 14:00 Opening & Welcome

• B Huntly (United Kingdom)

14:00 - 15:00 Opening talks

Chair: B Huntly (United Kingdom)

• Iron-dependent stemness control in healthy and malignant hematopoietic stem cells
  B Will (United States)
• The role of AML stem cells in patients treated with Venetoclax
  A Trumpp (Germany)

15:00 - 15:30 Coffee break

15:30 - 17:00 Session 1a - Metabolic dependencies in malignant hematopoiesis

Chair: A Trumpp (Germany)

• Metabolic dependencies in Germinal Centre derived B cell lymphomas
  A Ortega-Molina (Spain)
• Identification of metabolic vulnerabilities across the heterogeneous landscape of AML
  JJ Schuringa (the Netherlands)
• Serine/glycine synthesis addiction in T-cell malignancies
  K de Keersmaecker (Belgium)

17:00 - 18:00 Session 1b - Metabolic dependencies in malignant hematopoiesis

Chair: J-E Sarry (France) 

Abstract presentations

• Slc6a8-mediated creatine uptake regulates the anti-tumor immune response in acute myeloid leukemia
  P Apostolova (Switzerland)
• Malignant evolution in crebbp -|- diffuse large b cell lymphoma at single cell resolution identifies oxidative phosphorylation as a metabolic dependency.
  S Horton (United Kingdom)
• Metabolic plasticity reveals a targetable vulnerability in leukemia
  G Andrieu (France)
• Polyamine depletion targets human leukemia stem cells through decreased synthesis of proteins essential for the maintenance of stem cell function.
  C Jones (United States)
  

18:00 - 18:25 Poster pitch 1

Chair: B Huntly (United Kingdom)

5-minute flash talks from top poster presenters

• Autophagy is required for the metabolic adaptation and survival of acute lymphoblastic leukaemia cells in the central nervous system
  E Himonas (United Kingdom)
• Overcoming treatment resistance in precursor b-cell acute lymphoblastic with the novel amino acid degrader cyst(e)inase
  R Burt (United Kingdom)
• Increased oxidative phosphorylation drives relapse in tp53-altered t-cell acute leukemia
  S Gachet (France)
• The pyruvate kinase (pk) activator ag-946 improves pk properties and red blood cell (rbc) characteristics upon ex vivo treatment of rbcs from patients with myelodysplastic syndromes
  J de Wilde (the Netherlands)
  

18:25 - 20:00 Poster walk with reception

20:30 - 23:00 Dinner

09:00 - 10:30 Session 2a - Metabolism in erythropoiesis and megakaryocytopoiesis

Chair: M Muckenthaler (Germany)

• Lipid uptake and metabolism are essential for megakaryopoiesis and platelet production
  S Severin (France)
• Transcriptional control of differentiation- and metabolism-related genes during hematopoiesis: lessons from Drosophila.
  J Lenz (Germany)
• Dysregulated pathways in hereditary red blood cell disorders
  R Russo (Italy)

10:30 - 11:00 Coffee break

11:00 - 11:30 Session 2b - Metabolism in erythropoiesis and megakaryocytopoiesis

Chair: A Iolascon (Italy)

Abstract presentations

• Aging associated decline of chaperone-mediated autophagy (cma) activity mitigates clonal hematopoiesis and blocks leukemic transformation
  J Grimm (United States)
• Small molecule inhibition of mettl3 impacts specific haematopoietic lineages
  K Sturgess (United Kingdom)

11:30 - 12:15 Session 3b - Emerging technologies in hematology

Chair: A Trumpp (Germany)

Abstract presentations

• Metabolic rewiring in stress induced hematopoietic stem cell activation
  S Geiger (Germany)
• Metabolic dependencies and vulnerabilities of leukemic stem cells in Dnmt3a|npm1 mutant amls
  E Donato (Germany)
• Screening enhancers at nucleotide resolution using dense base editing and allele-based readout
  D Seruggia (Austria)

12:15 - 13:15 Lunch

13:15 - 14:45 Session 3a - Emerging technologies in hematology

Chair: S Haas (Germany)

• 3D engineering of human hematopoietic niches
  P Bourgine (Sweden)
• Blood stem cell expansion: technology to biology
  A Wilkinson (United Kingdom)
• Spatial tracing of cancer subclone organization by highly multiplexed protein and nucleic acid imaging
  F Hartmann (Germany)

14:45 - 15:15 Coffee break

15:15 - 16:45 Session 4a - Metal metabolism in malignant and non-malignant hematology

Chair: A Iolascon (Italy)

• Chemical Control of Cell Plasticity
  R Rodriguez (France)
• Reprograming the immune microenvironment with iron
  M Muckenthaler (Germany)
• Selenoprotein biosynthesis is a vulnerability of acute myeloid leukemia
  D Nakada (United States)

16:45 - 17:15 Poster pitch 2

Chair: S Haas (Germany)

Flash talks by top poster presenters

• The role of p300 mediated h3k27ac in enhancer function
  N Jackson (United Kingdom)
• Succinate receptor 1 signaling regulates hematopoiesis via s100|a8 and s100|a9 in health and malignancy
  V Cuminetti (Norway)
• The functional role of Musashi-2 uncovers potentially targetable metabolic vulnerabilities of infant ΚΜΤ2Α rearranged Β-cell acute lymphoblastic leukemia
  L Valsecchi (Italy)
• Unraveling the role of polypyrimidine tract binding protein 1 (ptbp1) in acute myeloid leukemia: at the cross-road between metabolism, proliferation and survival.
  M Ghisi (France)
• Targeting a lineage-specific pi3kɣ|akt signaling module in acute myeloid leukemia using a heterobifunctional degrader molecule
  L Kelly (France)
• Chronic lymphocytic leukemia cells are sensitive to apolipoprotein e-mediated disruption of lipid and copper homeostasis
  F Nardi (Italy)

17:15 - 18:45 Poster walk with reception

19:30 - 22:00 Dinner

09:00 - 09:30 Session 4b - Metal metabolism in malignant and non-malignant hematology

Chair: M Muckenthaler (Germany)

Abstract presentations

• Iron as nutrient and potential toxic element in b-acute lymphoblastic leukaemia
  MM Capelletti (Italy)
• Zmat3 prevents hematopoietic stem cell exhaustion and contributes to cell transformation by modulating sphingolipid metabolism in fanconi anemia disease.
  M Loock (France)

09:30 - 11:00 Session 5a - Functional screenings of molecular vulnerabilities

Chair: A Kabanova (Italy)

• Regulation of hematopoietic stem cell dormancy
  N Cabezas Wallscheid (Switzerland)
• Improving CD20-targeted immunotherapy in B-cell acute lymphoblastic leukemia
  M Firczuk (Poland)
• Using Functional Genomics to Overcome Therapy Resistance in Leukemia
  A Puissant (France)

11:00 - 11:30 Coffee break

11:30 - 12:15 Session 5b - Functional screenings of molecular vulnerabilities

Chair: B Will (United States)

Abstract presentations

• Systematic perturbation of metabolic regulators identifies distinct metabolic requirements in the control of proliferation, differentiation and stem cell maintenance in acute myeloid leukaemia
  N Narayan (United Kingdom)
• Identifying inflammatory mediators of clonal hematopoiesis
  I Fernandez Maestre (United States)
• Mitol dysfunction triggers apoptosis of hematopoietic stem cells via er stress response
  W Ma (United Kingdom)

12:15 - 13:15 Lunch break

13:30 - 22:00 Activity with dinner

09:00 - 10:30 Session 6a - Emerging molecular vulnerabilities in malignant hematopoiesis

Chair: B Will (United States)

• The opportunities and challenges of targeting essential metabolic traits of leukemic stem cells
  E Gottlieb (United States)
• Is the monosaccharide mannose a therapeutic option for acute myeloid leukaemia?
  K Ryan (United Kingdom)
• Investigating the vulnerability of leukaemia for their bone marrow microenvironment
  D Bonnet (United Kingdom)

10:30 - 11:00 Coffee break

11:00 - 12:00 Session 6b - Emerging molecular vulnerabilities in malignant hematopoiesis

Chair: J-E Sarry (France)

Abstract presentations

• Genetic or pharmacological inactivation of crebbp sensitises b-cell acute lymphoblastic leukaemia to ferroptotic cell death upon bcl2 inhibition
  S Richardson (United Kingdom)
• Metformin-induced ferroptosis is a therapeutic vulnerability in IDH2-mutant acute myeloid leukemia linked to metabolic rewiring towards fatty acid oxidation
  D Sternadt (the Netherlands)
• Characterizing the metabolism of relapse and relapse-fated clones in b-cell acute lymphoblastic leukemia
  S Smith (Canada)
• Targeting the mrna m6A readers ythdf1 and ythdf3 selectively compromise aml without affecting normal haeamatopoiesis
  H Lawson (United Kingdom)

12:00 - 12:30 Closing talk

• Metabolic adaptations and mitochondrial signaling circuits in drug resistance of acute myeloid leukemia
  J-E Sarry (France)

12:30 - 13:00 Closing ceremony + Awards

Chair: A Kabanova (Italy)

• Top 3 poster presentations receive an award

13:00 - 14:00 Farewell lunch + departure