To date, up to 80% of patients with the most common subtype of malignant lymphoma (diffuse large B-cell lymphoma), are cured of this aggressive disease by chemotherapy, in combination with the anti-lymphoma antibody Rituximab. Unfortunately, young patients with high risk disease and elderly patients fare much worse and there is an urgent need to improve their outcome. However, the past year has seen a significant increase in our knowledge of the biology of disease. Using gene expression profiling and other new molecular techniques, we are beginning to recognize/identify the disease driver pathways which make lymphoma cells continue to proliferate. These major advances will be extensively reported at the meeting.  The first results of clinical studies with new "smart molecules", such as lenalidomide, enzastaurin, bortezomib and ibrutinib, to mention a few, that specifically kill the cancer cells with only minimal damage to normal tissues/organs will be presented. So far, this modern "personalized medicine" approach appears to be promising, in particular for patients who only respond poorly to conventional treatment.